Comparison of Compertz and Logistic Models in Estimating the Growth of Leptin-Deficient (ob/ob) Mice and Wild-Type Mice Fed an In-House Prepared High-Fat Diet
Ah Reum Son, Hyunwoong Jo, Kyu Ree Park and Beob Gyun Kim
American Journal of Animal and Veterinary Sciences
This experiment was conducted to growth curve models for leptin-deficient (ob/ob) and wild-type mice fed a meal-form High-Fat (HF) diet prepared in-house for over 120 weeks. Two hundred and twenty-four sets of Body Weight (BW) and age data were collected from ob/ob mice and 485 sets of data were collected from wild-type mice. All animals had free access to the HF diet (34.3% energy from fat) and water. Individual BW and survival rates of mice were measured. To develop growth curves of ob/ob mice and wild-type mice fed the HF diet, Gompertz and Logistic growth models were employed. The survival rates of ob/ob mice fed the HF diet were lower than those of wild-type mice. Models for estimating growth of ob/ob mice fed the HF diet were: BW, g = 61.36 × e-2.56×e^-0.13t in Gompertz model (Akaike’s Information Criterion, AIC = 1,694); and BW, g = 60.65 × (1 + 7.04 × e-0.18t)-1 in Logistic model (AIC = 1,719). Growth models for wild-type mice fed the HF diet were: BW, g = 28.94 × e-1.75×e^-0.13t in Gompertz model (AIC = 3,171); and BW, g = 28.23 × (1 + 4.85 × e-0.25t)-1 in Logistic model (AIC = 3,198). In conclusion, Gompertz models may be more appropriate to estimate the growth of ob/ob mouse fed the diet with high-fat concentration.
© 2019 Ah Reum Son, Hyunwoong Jo, Kyu Ree Park and Beob Gyun Kim. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.