Current Research in Medicine

Detection of Extended-Spectrum β Lactamases and AmpC β-Lactamase Production in Escherichia coli Causing Urinary Tract Infection among HIV and Non-HIV Patients

Padmavathy Kesavaram, Padma Krishnan and Rajasekaran Sikhamani

DOI : 10.3844/amjsp.2011.54.58

Current Research in Medicine

Volume 2, Issue 1

Pages 54-58


Problem statement: Opportunistic infections have been documented as a leading cause of morbidity among HIV patients. Gram negative pathogens that elaborate beta-lactamases have been reported to be associated with increased morbidity and mortality, especially amongst immunocompromised patients on intensive care and high-dependency units. The most common mechanism of β-lactam drug resistance in Escherichia coli include ESBL, AmpC production. Approach: In this study, we assessed the prevalence of UTI in two groups of individuals which included patients with HIV/AIDS and non-HIV antenatal patients. Results: E. coli was the predominant pathogen associated with bacteriuria in both the HIV group and the non-HIV group. In vitro sensitivity revealed that 96.2 and 31.8% of the E. coli isolates from the HIV patients and non-HIV patients were resistant to co-trimoxazole. Also, 72.7 and 4.5% of E. coli strains produced ESBL and/or AmpC among the HIV and the non-HIV antenatal patients respectively. Conclusion: Our data suggests that UTI may represent a relevant cause of morbidity among the HIV/AIDS patients.


© 2011 Padmavathy Kesavaram, Padma Krishnan and Rajasekaran Sikhamani. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.