Research Article Open Access

Bilirubin Lowering Potential of Annona muricata (Linn.) In Temporary Jaundiced Rats

Fareed K.N. Arthur1, Eric Woode1, Ebenezer O. Terlabi1 and Christopher Larbie1
  • 1 Kwame Nkrumah University of Science and Technology, Ghana

Abstract

Problem statement: Annona muricata is used in Ghanaian traditional medicine for the treatment of jaundice. Work done has demonstrated A. muricata to be effective in treating carbon tetrachloride-and acetaminophen-induced hepatic damage, hepatic jaundice and toxicologically safe up to 1000 mg kg-1 in animals. Current study evaluated the bilirubin-lowering potential of A. muricata aqueous extract in phenylhydrazine-(40 mg kg-1) induced jaundice in adult rats. Approach: Jaundice was assessed by measuring the levels of total bilirubin and direct bilirubin in phenylhydrazine-treated animals with or without drug treatment with curative, prophylactic study and in animals with reduced liver capacity. Results: Phenylhydrazine induced jaundice in animals from 1.50 μmol L-1±0.00 total bilirubin in normal animals up to 29.25 μmol L-1±2.21 in animals with reduced liver capacity. The hyperbilirubinaemia were restored close to normal levels in animals treated with A. muricata aqueous extract at 50 and 400 mg kg-1. Total bilirubin level was reduced to 6.22 μmol L-1± 0.27 at 50 mg, 5.68 μmol L-1±0.36 at 400 mg kg-1 and 7.94 μmol L-1±0.79 with Silymarin, significantly lower (p<0.001) compared with the vehicle group (16.90 μmol L-1±2.21) maintained with distilled water. Conclusion: Therefore, A. muricata aqueous extract can be used to reduce bilirubin concentration in jaundiced subjects.

American Journal of Pharmacology and Toxicology
Volume 7 No. 2, 2012, 33-40

DOI: https://doi.org/10.3844/ajptsp.2012.33.40

Submitted On: 8 March 2012 Published On: 23 May 2012

How to Cite: Arthur, F. K., Woode, E., Terlabi, E. O. & Larbie, C. (2012). Bilirubin Lowering Potential of Annona muricata (Linn.) In Temporary Jaundiced Rats. American Journal of Pharmacology and Toxicology, 7(2), 33-40. https://doi.org/10.3844/ajptsp.2012.33.40

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Keywords

  • Phenylhydrazine
  • Annona muricata
  • bilirubin
  • jaundice
  • rats