American Journal of Pharmacology and Toxicology

Hepatic and Renal Histological Alterations Induced by Topical Hydroquinone Administration

Bashir M. Jarrar, Maher M. Alenezi, Abdullah Al-Hiri and Yazun Jarrar

DOI : 10.3844/ajptsp.2012.19.26

American Journal of Pharmacology and Toxicology

Volume 7, Issue 1

Pages 19-26


Problem statement: Although the regulatory agencies of the United States and Europe banned hydroquinone in cosmetics skin lightening but it is still used in most of Middle East countries, including Saudi Arabia. Few studies were carried out on the histological alterations of hydroquinone on kidney and liver. Approach: The present study was carried out to investigate the histological alterations in liver and kidney caused by hydroquinone topical administration. Results: The induced histological alterations in the liver were mainly hydropic degeneration, bile duct hyperplasia and glycogen depletion. The kidney of treated rabbits showed hydropic degeneration, hyaline casts, congestion, perivascular edema and fibrosis together with lymphocytic aggregation. The skin showed hyperkeratosis, lymphocytic and eosinophilic infiltration together with congestion of dermal blood vessels. Conclusion: Taken together, the histological findings of this study indicate that chronic exposure to hydroquinone produce significant histological alterations that might affect the liver and kidney.


© 2012 Bashir M. Jarrar, Maher M. Alenezi, Abdullah Al-Hiri and Yazun Jarrar. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.