Research Article Open Access

Zerumbone: A Natural Compound with Anti-Cholinesterase Activity

Ahmad Bustamam1, Siddig Ibrahim1, Adel S. Al-Zubairi1, Manal MET1 and M.M. Syam1
  • 1 Institute of Bioscience, Malaysia


Herbal dugs could be a new source for inhibitors of acetyl cholinesterase (anti-AChE), the key enzyme in the breakdown of acetylcholine and a new talented approach for the cure of elderly neurologically associated disorders such as Alzheimer’s disease (AD). Zerumbone (ZER) is sesquiterpene from the edible plant, Zingiber zerumbet which is known to possess tremendous biological activities. In this study, the inhibitory effect of ZER towards acetyl cholinesterase was evaluated using thin layer chromatography (TLC) bioautography and compared concurrently to tacrine, as positive control. The results obtained in this research showed that ZER has an enzymolytic effect towards AChE. It could be suggested that ZER might be a potential candidate for the development of anti-AD treatment.

American Journal of Pharmacology and Toxicology
Volume 3 No. 3, 2008, 209-211


Submitted On: 6 May 2008 Published On: 30 September 2008

How to Cite: Bustamam, A., Ibrahim, S., Al-Zubairi, A. S., MET, M. & Syam, M. (2008). Zerumbone: A Natural Compound with Anti-Cholinesterase Activity. American Journal of Pharmacology and Toxicology, 3(3), 209-211.

  • 16 Citations



  • Zingiber zerumbet
  • zerumbone
  • anti-cholinesterase drugs
  • TLC bioautography