American Journal of Pharmacology and Toxicology

The Effect of Vitamin C on the Metabolic Parameters of Experimental Diabetes Mellitus

Mariam Al-Shamsi, Amr Amin and Ernest Adeghate

DOI : 10.3844/ajptsp.2007.4.9

American Journal of Pharmacology and Toxicology

Volume 2, Issue 1

Pages 4-9


The role of vitamin C on diabetes mellitus is unknown. The purpose of this study was to examine the effect of oral administration of vitamin C on some of the metabolic parameters of diabetic rats. Diabetes was induced by intraperitoneal injection of STZ (60 mg kgˉ1 body weight at 12 weeks of age). Vitamin C (10, 50, 100 mg kgˉ1 body weight) was administered orally for a period of four weeks to normal and diabetic male Wistar rats. In some experiments vitamin C was given either before or after the induction of diabetes mellitus. Glucose tolerance test (GTT) was performed on fasted normal, diabetic and vitamin C-treated rats at the end of the experimental period. Blood sugar level and weight were also recorded on a weekly basis for each rat in different groups. Vitamin C significantly (p<0.05) reduced blood glucose level and decreased weight gain in experimental diabetes mellitus at all doses when compared to untreated rats. This beneficial effect of vitamin C on the hyperglycemia of diabetic rats was dose-dependent. Moreover, vitamin C also improved GTT in diabetic rats compared to untreated diabetic rats. In conclusion, vitamin C may play a role in insulin metabolism and thus be a useful adjuvant therapy in diabetes mellitus.


© 2007 Mariam Al-Shamsi, Amr Amin and Ernest Adeghate. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.