American Journal of Pharmacology and Toxicology

Evaluation of Local Injection of 0.5% Bupivacaine + 1/200000 Epinephrine for Post Tonsillectomy Pain Reduction

Keramat Mozafarinia and Maryam Amizadeh

DOI : 10.3844/ajptsp.2007.26.29

American Journal of Pharmacology and Toxicology

Volume 2, Issue 2

Pages 26-29


To determine the effectiveness of postoperative local infiltration of Bupivacaine in decreasing post tonsillectomy pain. A double blind randomized clinical trail was conducted. Treatment group was administered 3-10 ml 0.5% Bupivacaine + 1/200000 Epinephrine solution and control group was received 3-10 ml normal saline, locally. Outcome was post surgical pain, which measured by visual analogue scale (VAS), after 6, 12, 18 hours post surgical. The mean scores of pain after surgery were lower grade in treatment group than placebo group. Post tonsillectomy pain suffered patients and required to reduce; hence pharmacotherapy seems necessary for it. Current finding was shown local 0.5% Bupivacaine + 1/200000 Epinephrine injection is good for pain relief.


© 2007 Keramat Mozafarinia and Maryam Amizadeh. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.