The Role of SLC22A4 Gene Polymorphisms in the Response to Salbutamol in Asthmatic Patients
Alshymaa A. Ahmed, Nora M. Said, Alia A. El Shahaway and Nagwan A. Ismail
DOI : 10.3844/ajisp.2019.10.18
American Journal of Immunology
Volume 15, 2019
Response to Bronchodilators is influenced by many factors including genetics. To evaluate the influence of SLC22A4 gene polymorphisms (rs3792876 and rs2073838) on the response to inhaled salbutamol in asthmatic patients, bronchodilator response was assessed in 180 bronchial asthma patients via measuring changes of the Forced Expiratory Volume in one second (FEV1) after the administration of inhaled salbutamol and genotyping for rs3792876 and rs2073838 was carried out using real-time polymerase chain reaction. Frequencies of genotypes were compared in between responders and non-responders. The frequency of rs2073838 genotypes showed no significant differences. On the other hand, the recessive genotype of rs3792876 occurred more frequently among the non-responding patients P = 0.01, 95% confidence interval (1.2-9.5). The homozygous form of rs3792876 can influence the absorption of inhaled bronchodilator (Salbutamol), although, replication studies on this point are recommended.
© 2019 Alshymaa A. Ahmed, Nora M. Said, Alia A. El Shahaway and Nagwan A. Ismail. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.