Case Report Open Access

Clinical Case Report of a Novel Immunotherapeutic Approach to Autism Spectrum Disorders based on an emulsion of Chondroitin Sulfate, Vitamin D3 and Oleic Acid

Nicola Antonucci1, Stefania Pacini2 and Marco Ruggiero2
  • 1 Biomedical Centre for Autism Research and Treatment, Italy
  • 2 Arzo-Mendrisio, Switzerland
American Journal of Immunology
Volume 13 No. 3, 2017, 180-185

DOI: https://doi.org/10.3844/ajisp.2017.180.185

Published On: 10 August 2017

How to Cite: Antonucci, N., Pacini, S. & Ruggiero, M. (2017). Clinical Case Report of a Novel Immunotherapeutic Approach to Autism Spectrum Disorders based on an emulsion of Chondroitin Sulfate, Vitamin D3 and Oleic Acid. American Journal of Immunology, 13(3), 180-185. https://doi.org/10.3844/ajisp.2017.180.185

Abstract

In this clinical case report we describe the effects associated with the administration of a supplement constituted by chondroitin sulfate, vitamin D3 and oleic acid (Rerum®) on the symptoms of Autism Spectrum Disorders (ASD). 44 patients (11 females and 33 males) were administered this supplement for a period of two months and variations of symptomatology were evaluated by the Clinical Global Impression of Improvement (CGI-I). 32 out of 44 subjects (73%), showed improvements in the two months of observation. In the group of female subjects, 9 out of 11 (81%) showed improvements and, among these, 6 out of 9 (66%) showed moderate to very considerable improvements. In the group of male subjects, 24 out of 33 (73%) showed improvements and, among these, 22 out of 24 (91%) showed moderate to very considerable improvements. We attribute these remarkable results to the effects of the supplement on the endocannabinoid system as it relates to neuro-inflammation and neuro-immune alterations.

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Keywords

  • Autism
  • Endocannabinoid
  • GcMAF
  • Chondroitin Sulfate
  • Vitamin D3
  • Oleic Acid