American Journal of Immunology

Double Application of Translocator Protein Ligands and RAW Cells Inflammatory Milieu

Maria Staykova, Filomena Mattner, David Linares and Andrew Katsifis

DOI : 10.3844/ajisp.2016.56.60

American Journal of Immunology

Volume 12, Issue 3

Pages 56-60


Ligands targeting the translocator protein exhibit a variety of anti-inflammatory and neuroprotective properties. A double application of eight translocator protein ligands to activated murine macrophage-like cells changed to a different extent the levels of secreted reactive nitrogen intermediates, pro- and anti-inflammatory cytokines. To our knowledge this is the first report suggesting that multiple applications of different translocator protein ligands may have selective effects on the macrophage inflammatory milieu that do not appear to be related to just the ligand affinity.


© 2016 Maria Staykova, Filomena Mattner, David Linares and Andrew Katsifis. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.