American Journal of Immunology

A Novel Glucan-Sulforaphane Combination Stimulates Immune Response to Influenza in Mouse Model

Vetvicka Vaclav and Vetvickova Jana

DOI : 10.3844/ajisp.2016.20.28

American Journal of Immunology

Volume 12, Issue 2

Pages 20-28


Influenza remains a serious health problem and causes approximately 500,000 deaths world-wide. With current available treatments offering neither dependable protection nor a rapid cure, many have focused their attention to alternative treatments. The aim of this study was to evaluate the possible effect of a novel maitake glucan-sulforaphane combination on immune response against influenza challenge in mice. We evaluated the effects of a glucan-sulforaphane combination on basic immune reactions, virus titre and overall survival after influenza infection. Results: We found 2 weeks supplementation with this glucan-sulforaphane combination significantly improved immunosuppression caused by the viral infection. Based on these results, we conclude that the significant immunostimulation caused by this combination helps to overcome virus-dependent suppression of defense reactions and that addition of sulforaphane to glucan can improve already established biological effects of glucan.


© 2016 Vetvicka Vaclav and Vetvickova Jana. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.