American Journal of Immunology

Leukemia and Therapy

N. B. Alitheen, S. K. Yeap, N. H. Faujan, W. Y. Ho, B. K. Beh and A. R. Mashitoh

DOI : 10.3844/ajisp.2011.54.61

American Journal of Immunology

Volume 7, Issue 4

Pages 54-61


Problem statement: Leukemia is a cancer which linked intimately with the immune system. It is a group of heterogenous neoplastic disorder of white blood cells characterized by the uncontrolled proliferation and block in differentiation of hematopoeitic cells. Generally, leukemia can be classified into myeloid or lymphoid referring to the type of abnormal cell found most in the blood. Approach: Many drug discovery researches have utilized the leukemic cell lines to screen for their potential as chemotherapy agents for leukemia. Results: The understanding on the types of leukemia and current choice of chemotherapy drugs can help to select the best target cell lines to study and the most suitable chemotherapy drug as positive control. Conclusion/Recommendations: This review cover types of leukemia, current option of chemotherapy drugs and some potential cytotoxic and immunomodulatory natural products targeting leukemic cancer cell line.


© 2011 N. B. Alitheen, S. K. Yeap, N. H. Faujan, W. Y. Ho, B. K. Beh and A. R. Mashitoh. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.