Research Article Open Access

Evaluation of Immunomodulatory Effect: Selection of the Correct Targets for Immunostimulation Study

Swee Keong Yeap1, Mashitoh Binti Abd Rahman2, Noorjahan Banu Alitheen2, Wan Yong Ho2, Abdul Rahman Omar2, Boon Kee Beh2 and Huynh Ky3
  • 1 Institute of Bioscience, Malaysia
  • 2 Universiti Putra Malaysia, Malaysia
  • 3 Cantho University, Vietnam

Abstract

Problem statement: Numerous plants or remedies that are traditionally used for various diseases had been claimed to maintain general good health, particularly the immune system. With the advanced understanding on immunology and ethnopharmacology, study on the interaction of this herb with the immune system is critical to understand the safety and its efficacy as a potent immunomodulatory agent. Approach: Selecting proper immune cells from a suitable immune organ allowed for the understanding on the mode of immunomodulation. Lymphocytes isolated from mammalian thymus, spleen and bone marrow represented great candidates for this immunomodulatory study. Results: A number of herbal extracts including that of Rhaphidophora korthalsii and compounds isolated from this plant, namely lectin and zerumbone, had been identified as potent immunostimulators. Conclusion/Recommendations: Future studies are needed to elucidate the mechanism underlaying activites of these immunomodulatory agents.

American Journal of Immunology
Volume 7 No. 2, 2011, 17-23

DOI: https://doi.org/10.3844/ajisp.2011.17.23

Submitted On: 1 October 2011 Published On: 4 November 2011

How to Cite: Yeap, S. K., Rahman, M. B. A., Alitheen, N. B., Ho, W. Y., Omar, A. R., Beh, B. K. & Ky, H. (2011). Evaluation of Immunomodulatory Effect: Selection of the Correct Targets for Immunostimulation Study. American Journal of Immunology, 7(2), 17-23. https://doi.org/10.3844/ajisp.2011.17.23

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Keywords

  • Immunomodulation
  • PBMC
  • spleen
  • mitogen