Evaluation of Immunomodulatory Effect: Selection of the Correct Targets for Immunostimulation Study
Swee Keong Yeap, Mashitoh Binti Abd Rahman, Noorjahan Banu Alitheen, Wan Yong Ho, Abdul Rahman Omar, Boon Kee Beh and Huynh Ky
DOI : 10.3844/ajisp.2011.17.23
American Journal of Immunology
Volume 7, Issue 2
Problem statement: Numerous plants or remedies that are traditionally used for various diseases had been claimed to maintain general good health, particularly the immune system. With the advanced understanding on immunology and ethnopharmacology, study on the interaction of this herb with the immune system is critical to understand the safety and its efficacy as a potent immunomodulatory agent. Approach: Selecting proper immune cells from a suitable immune organ allowed for the understanding on the mode of immunomodulation. Lymphocytes isolated from mammalian thymus, spleen and bone marrow represented great candidates for this immunomodulatory study. Results: A number of herbal extracts including that of Rhaphidophora korthalsii and compounds isolated from this plant, namely lectin and zerumbone, had been identified as potent immunostimulators. Conclusion/Recommendations: Future studies are needed to elucidate the mechanism underlaying activites of these immunomodulatory agents.
© 2011 Swee Keong Yeap, Mashitoh Binti Abd Rahman, Noorjahan Banu Alitheen, Wan Yong Ho, Abdul Rahman Omar, Boon Kee Beh and Huynh Ky. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.