American Journal of Immunology

Immunologic Response to Hepatitis B Vaccine in Health Care Workers: A Screening Program and Evaluation of Some Host-Related Factors Role

Mojtaba Varshochi and Roghayyeh Mahmodian

DOI : 10.3844/ajisp.2011.12.16

American Journal of Immunology

Volume 7, Issue 1

Pages 12-16


Problem statement: To evaluation the immunologic response to hepatitis B vaccine in health care’s workers and effects of host-related factors? Approach: In a cross sectional descriptive analytic study carried out on the medical staff of Tabriz Shahid Madani Hospital in 2009-2010, we evaluated the immunologic response of the staff to vaccination against Hepatitis B and factors affecting it. Results: The mean antibody titer in the studied medical staff was 366.76±169.714 IU L-1. 2.05% were in “no response” group, 1.46% in “Low response” group and 96.49% in “Good response” group. Conclusion: Immunological response in the smoking staff was significantly less (p < 0.001) but no significant difference was observed in the response between genders (p = 0.127) and no case of hyperlipidemia was reported. There was a significant reverse linear relation between age and antibody titer in the studied staff (p = 0.003, R = 0.162) but no significant linear relation was observed between weight, height and BMI and antibody titer.


© 2011 Mojtaba Varshochi and Roghayyeh Mahmodian. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.