Case Report Open Access

Cryptococcal Meningoencephalitis in a Patient with Hyper IgM Syndrome Due to CD40 Deficiency: Case Report and Literature Review

Maram Al-Banyan1, Abdulhadi Alqahtani1, Farrukh Sheikh1, Agha M. Rehan Khaliq2, Hasan Al Rayes1, Ashraf Al-Tarifi1, Bandar Al-Saud1 and Rand K. Arnaout2
  • 1 King Faisal Specialist Hospital and Research Centre, Saudi Arabia
  • 2 Alfaisal University, Saudi Arabia

Abstract

Hyper-IgM syndrome (HIGM) due to CD40 deficiency is a very rare form of combined immunodeficiency with increased susceptibility to opportunistic infections. Cryptococcus is an opportunistic infection usually affecting immunocompromised individuals. This is the first report to describe a patient with HIGM due to CD40 deficiency presenting with meningoencephalitis secondary to Cryptococcus infection.

American Journal of Infectious Diseases
Volume 15 No. 1, 2019, 24-28

DOI: https://doi.org/10.3844/ajidsp.2019.24.28

Submitted On: 28 November 2018 Published On: 22 February 2019

How to Cite: Al-Banyan, M., Alqahtani, A., Sheikh, F., Khaliq, A. M. R., Al Rayes, H., Al-Tarifi, A., Al-Saud, B. & Arnaout, R. K. (2019). Cryptococcal Meningoencephalitis in a Patient with Hyper IgM Syndrome Due to CD40 Deficiency: Case Report and Literature Review. American Journal of Infectious Diseases, 15(1), 24-28. https://doi.org/10.3844/ajidsp.2019.24.28

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Keywords

  • Hyper-IgM Syndrome
  • Cryptococcus Neoformans
  • Meningoencephalitis
  • Primary Immunodeficiency