Research Article Open Access

Multidrug Resistant Uropathogens among Egyptian Pregnant Women

Wafaa Salah Metwally1 and Walid Mohamed Elnagar1
  • 1 Zagazig University, Egypt
American Journal of Infectious Diseases
Volume 15 No. 4, 2019, 115-122

DOI: https://doi.org/10.3844/ajidsp.2019.115.122

Submitted On: 10 July 2019
Published On: 21 December 2019

How to Cite: Metwally, W. S. & Elnagar, W. M. (2019). Multidrug Resistant Uropathogens among Egyptian Pregnant Women. American Journal of Infectious Diseases, 15(4), 115-122. https://doi.org/10.3844/ajidsp.2019.115.122

Abstract

Urinary Tract Infections (UTIs) in pregnancy is a common medical problem associated with significant increase in the risk of fetal morbidity and mortality. The effective appropriate antimicrobial agent is a major concern as many effective antimicrobial groups cannot be used due to their potential toxicity to the fetus as well as the increasing rates of Multidrug-Resistant (MDR) strain isolation. This cross- sectional study was conducted on women attending the antenatal care of Zagazig University. This study aimed to estimate prevalence of various uropathogens in UTI among the pregnant women and determine their antimicrobial resistance patterns. Clean catch mid-stream urine samples were obtained, complete microbiological examination and antibiotic susceptibility testing were carried out. More than half of culture positive samples was obtained from asymptomatic pregnant women. Asymptomatic bacteriuria was more common among primigravida, women of low socioeconomic class and with history of previous Cesarean section. Gram negative bacterial isolates were the most prevalent (71%). The most frequently isolated pathogens were: E. coli 34%, K. pneumoniae 26% and S. saprophyticus 23%, among the total Gram negative isolates, 95.0% were MDR. Meropenem was the antibiotic with the highest susceptibility rate (96%) on E coli isolates, followed by nitrofurantoin (74%) and tobramycin (72%). Recommendations: Urine culture and sensitivity must be the role as MDR pathogens are increasing, rationalization of antibiotic administration is a must.

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Keywords

  • MDR
  • Bacteriuria
  • Pregnancy