American Journal of Infectious Diseases

Monocytes and their Role in Human Immunodeficiency Virus Pathogenesis

Tara Sassé, Jingqin Wu, Li Zhou and Nitin K. Saksena

DOI : 10.3844/ajidsp.2012.92.105

American Journal of Infectious Diseases

Volume 8, Issue 2

Pages 92-105


Monocytes play several significant immunological roles during HIV infection. The phenotypic pliability and the cellular differentiation ability monocytes possess are crucial to the ways they combat infections and control inflammatory processes. The purpose of this review is to provide a comprehensive snapshot of the importance of monocytes in HIV-1 infection and pathogenesis. Moreover, this review also provides newly emerging data on how HIV leads to the subversion and manipulation of monocyte transcriptome and proteome, which may have implications in understanding the genomic and proteomic basis of monocyte function and its interaction with HIV.


© 2012 Tara Sassé, Jingqin Wu, Li Zhou and Nitin K. Saksena. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.