American Journal of Infectious Diseases

Retinoids and Opioids: Factors in the Development of HIV-Related Neurological Disease

Walter Royal, III and Joseph L. Bryant

DOI : 10.3844/ajidsp.2008.140.146

American Journal of Infectious Diseases

Volume 4, Issue 2

Pages 140-146


Neurological disease occurs frequently in HIV-infected individuals and may occur at even higher rates among infected drug users. Among the potential mechanisms that promote such impairment, retinoid deficiency may have selective effects that could both lead to alterations in immune function and enhanced replication of HIV. Studies are currently underway to examine the possible selective effects of retinoid receptor activation and interactions with opioids on the pathogenesis of neurological disease in the transgenic rat model of HIV infection.


© 2008 Walter Royal, III and Joseph L. Bryant. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.