Highlight of New Phosphodiesterase 10A Inhibitors Using Molecular Docking
Halla Belhoula, El Hassen Mokrani, Abderrahmane Bensegueni and Djihane Bioud
DOI : 10.3844/ajbsp.2019.34.37
Current Research in Bioinformatics
Volume 8, 2019
Phosphodiesterase 10A (PDE 10A) is an effective therapeutic approach for treatments of Schizophrenia (SCZ). In order to identify in silico new potent PDE 10A inhibitors, molecular docking approach was used. In this context, the compound S235 was predicted to exhibit a high potential PDE 10A inhibitory activity among 369 compounds tested. The predicted binding energy of this compound was improved from -10.28 to -13.80 Kcal/mol by structural replacements of its chemical grouping. Finally, the proposed compound was predicted to have good ADMET properties.
© 2019 Halla Belhoula, El Hassen Mokrani, Abderrahmane Bensegueni and Djihane Bioud. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.