Micrornas are Not That Small to Ignore
- 1 University of Cincinnati, United States
Abstract
MicroRNAs (miRNAs) are small, noncoding RNA molecule that negatively regulates gene expression by causing either degradation or translational inhibition of their target mRNAs. These miRNAs are key regulators of various biological processes such as differentiation, maturation and maintenance of immune homeostasis. Furthermore, deregulated expression of miRNA has now been shown to regulate several disease processes by regulating tumorigenesis, angiogenesis, apoptosis and metastasis in cancer and other diseases such as rheumatoid arthritis, diabetes and cardiovascular diseases. This review article summarizes the present status of miRNA research, with major emphasis on the roles of miRNAs in the development of various human diseases.
DOI: https://doi.org/10.3844/ajbbsp.2012.63.70
Copyright: © 2012 Sanjeev Kumar Srivastava, Sonal Somvanshi and Vivek Pratap Singh. This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Keywords
- MicroRNA
- diabetes
- cardiovascular disease
- cancer