Research Article Open Access

Dengue during Pregnancy: A Study of Thirteen Cases

Christiane Fernandes Alvarenga1, Vânia Glória Silami2, Patrícia Brasil3, Maria Elizabeth Herdy Boechat1, Janice Coelho3 and Rita Maria Ribeiro Nogueira4
  • 1 Teixeira de Freitas Street, Brazil
  • 2 Universitary Hospital Antonio Pedro, Brazil
  • 3 Institute of Clinical Research Evandro Chagas/Fiocruz, Brazil
  • 4 Flavirus Laboratory of the Oswaldo Cruz Institute /Fiocruz, Brazil

Abstract

Problem statement: The principal aim was to evaluate the effects of dengue virus infection by dengue during pregnancy and analyze the histopathology of the placenta. Approach: A retrospective study was conducted with 13 pregnant women with dengue confirmed in the period from January-December 2002, during a widespread dengue type 3 epidemic in Rio de Janeiro. Maternal and newborn data were collected from patient files and medical records during hospitalization for research for identification of dengue IgM antibodies (PanBio, Australia). Virus isolation was performed on all fatal cases and anathomopathological studies and immunohistochemistry of the placenta were carried out in three cases. Results: Among the 13 women, 11 (84, 6%) were infected in the third quarter of pregnancy, 6 (54, 5%) of which resulting in premature birth and 4 cases (30, 7%) were classified as DHF, causing 2 deaths. Intense abdominal pain afflicted 6 patients (46, 2%) and 5 newborns presented low weight, however appropriate for the gestacional age. Conclusion: Dengue virus infection in pregnancy increases premature birth risk, especially if the infection occurs in the last quarter of pregnancy.

American Journal of Infectious Diseases
Volume 5 No. 4, 2009, 288-293

DOI: https://doi.org/10.3844/ajidsp.2009.288.293

Submitted On: 28 March 2009 Published On: 31 December 2009

How to Cite: Alvarenga, C. F., Silami, V. G., Brasil, P., Boechat, M. E. H., Coelho, J. & Nogueira, R. M. R. (2009). Dengue during Pregnancy: A Study of Thirteen Cases. American Journal of Infectious Diseases, 5(4), 288-293. https://doi.org/10.3844/ajidsp.2009.288.293

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Keywords

  • Dengue
  • pregnancy
  • premature birth
  • ARDS
  • placenta