TY - JOUR AU - Hertiani, Triana AU - Purwantiningsih, AU - Winanta, Aji AU - Sasikirana, Widyandani AU - Munawaroh, Rima AU - Setyowati, Erna Prawita AU - Murwanti, Retno AU - Siswadi, PY - 2019 TI - In Vitro Immunomodulatory and Cytotoxic Potentials of Faloak (Sterculia quadrifida R.Br.) Bark JF - OnLine Journal of Biological Sciences VL - 19 IS - 4 DO - 10.3844/ojbsci.2019.222.231 UR - https://thescipub.com/abstract/ojbsci.2019.222.231 AB - Faloak (Sterculia quadrifida R.Br., Sterculiaceae) is an Indonesia indigenous plant widely used as a traditional remedy for various health complaints. This study aimed to explore the immunomodulatory and cytotoxicity potentials of Faloak bark by using in vitro techniques. Barks was extracted using water, ethanol and ethanol: water (1:1) separately. Colorimetric analysis was used for the determination of the total phenolic and the total flavonoid contents. Immunomodulator activities of the extracts were evaluated by studying their effects on mice macrophages and lymphocytes using in vitro methods, while the cytotoxicity potential was evaluated against Vero and HepG2 cell lines. The active extract was further fractionated and tested using different cell lines by the MTT method. Data were analyzed using one-way ANOVA and LSD tests, with a 95% confidence level (p