TY  - JOUR
AU  - Dahmani, Dahbia Ines 
AU  - Salem, Ikhlass Haj 
AU  - Chakir, Jamila 
AU  - Sifi, Karima 
AU  - Abderrahim, Sellami 
AU  - Bachtarzi, Mounir Zhary 
AU  - Malki, Sara 
AU  - Rouabah, Laila 
AU  - Abadi, Nore-Eddine 
AU  - Hacene, Mehdioui 
AU  - Bougrida, Mohamed 
AU  - Rouabhia, Mahmoud 
PY  - 2017
TI  -  Association of High-Affinity FcεRI-β intron 2 for IgE Gene Polymorphism and Atopic Diseases in an Algerian Population
JF  - OnLine Journal of Biological Sciences
VL  - 17
IS  - 4
DO  - 10.3844/ojbsci.2017.260.269
UR  - https://thescipub.com/abstract/ojbsci.2017.260.269
AB  - Atopy is characterized by the production of a high level of IgE in response to common allergens. We examined the RsaI-in2 polymorphism of the FcεRI-β gene and its association with atopic asthma and comorbidity. The study population included 77 atopic asthmatics and 77 non-atopic, non-allergic and non-asthmatic controls. Atopic asthma was confirmed by the skin prick test and by IgE and interleukin IL-4 levels. RsaI-in2 polymorphism was determined by RFLP-PCR using the RsaI enzyme. A significant correlation was found between genotype BB and sensitization to house dust mites in the asthmatic subjects (p = 0.000). Results also reveal significant allele sharing in the subjects affected by eczema (p = 0.000) and allergic rhinitis (p = 0.01) during childhood. Furthermore, the subjects with heterozygous AB and homozygous BB genotypes displayed significant IgE levels > 1000 UI mL-1. IL-4 levels were also > 1000 pmol/ml for RsaI-in2 polymorphism genotype BB. Our findings show a strong association between genotype BB and the incidence of eczema and allergic rhinitis in childhood as well as increased IgE and IL-4 levels.