@article {10.3844/ojbsci.2016.1.9,
article_type = {journal},
title = {Proposed Insights in the Pharmaco-Dynamic Theory of Ascorbate Pro-Oxidant Activity},
author = {Kerboua, Kheir Eddine and Haiba, Fatma and Bendjemia, Fatima and Kerrache, Mimouna and Boumediene, Amina},
volume = {16},
number = {1},
year = {2015},
month = {Nov},
pages = {1-9},
doi = {10.3844/ojbsci.2016.1.9},
url = {https://thescipub.com/abstract/ojbsci.2016.1.9},
abstract = {Ascorbate pro-drug theory promising possible effective and nontoxic treatment is intensively examined and centered on the importance of both extracellular and intra-cellular effects of ascorbate. In this study, we sought to determine the in vitro cell responsiveness in a plasma free milieu with or without an extracellular catalyst and/or hydrogen peroxide. This project brought to light how ascorbic acid would react to in a Red Blood Cell (RBC) suspension by using the two anti-oxidant pathways. We demonstrated that while ascorbate doesn’t require an extracellular metal catalyst to induce cell damage via the lipid peroxidation pathway, the protein-centered metal pathway could be enhanced by a divalent cation, hydrogen peroxide or both. The current lack of understanding of ascorbate potential mechanism excites us to propose some insights for the vitamine C pharmacologic dose pro-oxidant activity.},
journal = {OnLine Journal of Biological Sciences},
publisher = {Science Publications}
}