TY  - JOUR
AU  - Stutz, Dalla Santa Herta 
AU  - Rosália, Rubel 
AU  - Destéfanis, Vitola Francisco Menino 
AU  - Fan, Leifa 
AU  - Lucia, Tararthuch Ana 
AU  - Hermênio,, Lima Filho Cavalcante José 
AU  - Cavalcante, Figueiredo Bonald 
AU  - Roberto, Dalla Santa Osmar 
AU  - dos Santos, Raymundo Melissa 
AU  - Sasha, Habu 
AU  - Ricardo, Soccol Carlos 
PY  - 2009
TI  - Kidney Function Indices in Mice after Long Intake of Agaricus brasiliensis Mycelia (=Agaricus blazei, Agaricus subrufescens) Produced by Solid State Cultivation
JF  - OnLine Journal of Biological Sciences
VL  - 9
IS  - 1
DO  - 10.3844/ojbsci.2009.21.28
UR  - https://thescipub.com/abstract/ojbsci.2009.21.28
AB  - Problem statement: Agaricus brasiliensis (=Agaricus blazei, Agaricus 
subrufescens) or Sun mushroom has widespread use for potential health benefits 
such anti-tumor and immunomodulatory effects. Studies detected that others edible 
mushrooms affected renal metabolism and despite the widespread use of A. brasiliensis 
there are no studies that address biological effects on the renal function indices 
after their oral administration. Therefore, this study had as objective to verify 
the effects on kidney function indices after long intake of A. brasiliensis mycelium. 
Approach: Wheat grains was cultured during 18 days with Agaricus 
brasiliensis mycelium by solid state culture and used for chown formulation. Groups 
of female Swiss mice (20 per group) were fed during 14 weeks with 100 and 50% 
of the formulated feed denominated A100 and A50, respectively. Control group received 
formulated chown with wheat grains without mycelium. The water intake and excreted 
urine volume; the physic chemistry analysis of the urine and the serum levels 
of glucose, proteins, urea, creatinin and uric acid was determined (Meditron Junior-Boehringer, 
reagent strips Combur 10; microscopy and ADVIA 1650 Bayer). Results: 
A100 and A50 groups ingested 19.1 and 15.8% more water compared to C group, respectively. 
The urine and serum analysis showed that the verified parameters remained invariables 
for all groups, including glucose levels, which resulted in a 10% reduction of 
A100 group, without statistical difference (p>0.05 Vs C). Conclusion/Recommendations: 
The prolonged intake of supplemented feed with A. brasiliensis mycelium didn’t result in indicative alterations in the kidney function indices. The preventive use of the mushroom did not show any deleterious effects on kidney; however complementary studies are necessary to guarantee complete safety; possible correlation between increase of urinary excretion and hypotensive effect reported in the literature and also studies with diabetics animals to verify an possible hypoglycemic effect of the A. brasiliensis mycelium.