@article {10.3844/amjsp.2011.40.46,
article_type = {journal},
title = {Zeta Chain-Associated Protein-70 Expression is a Prognostic Tool in Mature and Precursor B-Cell Neoplasm},
author = {ElMenshawy, Nadia E. and ElAziz, Sherin A. Abd and El Deghadi, Heba A. and Mahfoz, Rabab M. and Metwali, Abd El-Hameed A.},
volume = {2},
year = {2011},
month = {Jul},
pages = {40-46},
doi = {10.3844/amjsp.2011.40.46},
url = {https://thescipub.com/abstract/amjsp.2011.40.46},
abstract = {Problem statement: The Zeta Chain-Associated Protein (ZAP) is a 70-kDa molecule
associated with the zeta chain of the CD3 receptor complex of the lymphocyte population. It plays an
important role in signaling initiation, activation T-cell receptor, phosphorylation of multiple
downstream targets. So that believed as T. lymphocyte specific .Several studies is gathering that the
pattern of expression is not lineage specific. We aimed to study the role of ZAP-70 /CD38 as new
prognostic marker in CLL and its prognostic value in ALL patients. Approach: Our study included 49
ALL ranged from 2-42 years they were 27 males and 22 females. One hundred fifty six patients with
CLL. They were 87 males and 69 females, their ages ranged from 50-77 yearsImmunophenotyping. by
flow cytometry (EPICS XL-2and 4 color Bechman Coulter USA), intracellular ZAP70 protein was
assessed by flow cytometry using (Caltag laboratories, Beckman Coulter USA). Results:
Immunophenotyping of 49 ALL patients ZAP-70 was found at significantly higher levels in T-ALL
cases compared with B-lineage (p},
journal = {Current Research in Medicine},
publisher = {Science Publications}
}