@article {10.3844/amjsp.2010.120.125,
article_type = {journal},
title = {First Report of Human Immunodeficiency Virus Type 1 Circulating Recombinant Form 02_AG Recombinant Strain of African Origin from North India},
author = {Neogi, Ujjwal and Sood, Vikas and Choudhury, Arpita and Das, Shukla and Ramachandran, V G. and Wanchu, Ajay and Banerjea, Akhil C.},
volume = {1},
year = {2010},
month = {Oct},
pages = {120-125},
doi = {10.3844/amjsp.2010.120.125},
url = {https://thescipub.com/abstract/amjsp.2010.120.125},
abstract = {Problem statement: Human Immunodeficiency Virus Type-1 (HIV-1) displays extensive genetic diversity globally which poses a serious challenge in making efficacious vaccine and developing effective therapeutic interventions. HIV-1 epidemic in India is largely driven by genetic subtype C but lately a number of reports suggest the presence of circulating recombinant forms and unique recombinant forms from different states of India. Approach: We analyzed 13 envelope sequences spanning the region from V1-V5 from three regions of North India and subjected to extensive genetic analysis. Results: We identified equal numbers (n = 6) of subtype C and CRF02_AG recombinant strain and a single subtype B-specific envelope. The extensive phylogenetic analysis of our CRF02_AG strains indicate that they are closely related to Central and Central-West African strains. The analysis of intra-subtype nucleotide distance revealed that the subtype C sequences are significantly more divergent and diverse than CRF02_AG strains (p},
journal = {Current Research in Medicine},
publisher = {Science Publications}
}