@article {10.3844/amjsp.2010.1.7,
article_type = {journal},
title = {Hepatotoxicity Due to Histamine Trifluoro-Methyl Toluidide, Amthamine, R-(-)-α-Methyl Histamine and Clobenpropit (H1R-H4R-Agonists, Respectively) in Rabbit Experimental Model},
author = {Tripathi, Trivendra and Khan, Aijaz Ahmed and Shahid, Mohammad and Khan, Haris M. and Siddiqui, Mashiatullah and Khan, Rahat Ali and Mahdi, Abbas Ali},
volume = {1},
year = {2010},
month = {Jun},
pages = {1-7},
doi = {10.3844/amjsp.2010.1.7},
url = {https://thescipub.com/abstract/amjsp.2010.1.7},
abstract = {Problem statement: Since in vivo  studies looking for toxicological impact of histamine receptors-agonists in experimental models are fragmentary, the present study was designed to delineate the histopathological and biochemical changes in livers of rabbits treated with histamine receptors (H1R-H4R)-agonists. Approach: The cohort comprised of six groups (Group I control and Group II-VI treated) containing five rabbits each. Control-group received vehicle (sterile distilled water) and treated groups received subcutaneous histamine (100 µg kg-1 × b.i.d.) and H1R-agonist (HTMT dimaleate), H2R-agonist (amthamine dihydrobromide), H3R-agonist (R-(-)-α-methylhistamine dihydrobromide) and H4R-agonist (clobenpropit dihydrobromide) each in a dose of 10 µg kg-1 × b.i.d. Hepatotoxicity due to these agonists analyzed by using histopathological and biochemical methods. Results: Rabbits treated with drugs in group II-VI had significant elevated levels of serum enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase and bilirubin) (p},
journal = {Current Research in Medicine},
publisher = {Science Publications}
}