@article {10.3844/ajptsp.2017.1.6, article_type = {journal}, title = {Exploration of Antidiabetic and Hypolipidemic Activity of Roots of Croton Zambesicus}, author = {Kumar, Prakash and Kumar, Rahul and Rastogi, Manoj Kumar and Murti, Krishna}, volume = {12}, year = {2017}, month = {Jun}, pages = {1-6}, doi = {10.3844/ajptsp.2017.1.6}, url = {https://thescipub.com/abstract/ajptsp.2017.1.6}, abstract = {The aim of this study was to investigate the potential antidiabetic and hypolipidaemic effects of aqueous and ethanolic extracts of roots of Croton zambesicus in alloxan induced diabetic models to ascertain its pharmacological applicability. The roots of Croton zambesicus were collected, dried and extracted. The phytochemical screening as well as Median Lethal Dose determination (LD50) was done. The ethanolic extract of the roots was prepared using soxhelation technique while the aqueous extract was prepared using maceration technique. The pharmacological effects of the two extracts were monitored on the blood glucose level and the lipidprofile for a period of 28 days on the alloxan induced diabetic rats and their effect was evaluated. The ethanolic (100 mg kg-1) and aqueous (100 mg kg-1) extracts caused a significant (p}, journal = {American Journal of Pharmacology and Toxicology}, publisher = {Science Publications} }