TY  - JOUR
AU  - Ngoula, Ferdinand 
AU  - Watcho, Pierre 
AU  - Kenfack, Augustave 
AU  - Manga, Joseph N’zouk 
AU  - Defang, Henry Fualefac 
AU  - Pierre, Kamtchouing 
AU  - Joseph, Tchoumboue 
PY  - 2014
TI  - EFFECT OF DIMETHOATE (AN ORGANOPHOSPHATE INSECTICIDE) ON THE REPRODUCTIVE SYSTEM AND FERTILITY OF ADULT MALE RAT
JF  - American Journal of Pharmacology and Toxicology
VL  - 9
IS  - 1
DO  - 10.3844/ajptsp.2014.75.83
UR  - https://thescipub.com/abstract/ajptsp.2014.75.83
AB  - The pesticides are one of the most potentially harmful chemicals liberated in the environment in an unplanned manner. Dimethoate is widely used as a potent pesticide in many countries and has been shown to produce some adverse health effects. In the present study, we investigated the effect of dimethoate (an organophosphate insecticide) on the reproductive system and fertility of male rats and the possible mechanism underlining its action. Twenty four adult Wistar male rats were divided into 4 groups of 6 animals per group  and force-fed with 0, 3.66, 5.50 and 11 mg kg-1 body weight of dimethoate for 90 days. At 80 days of treatment, each males was allows to mate with two primiparous cyclic females. The results showed a significant decrease (p