@article {10.3844/ajptsp.2010.34.41,
article_type = {journal},
title = {Taurine Implicated in Bromocriptine Induced Hallucination: Glycine-Glutamic-Aspartic Implicated in Bromocriptine Induced Schizophrenia},
author = {Jayyab, Abdulrahim Abu},
volume = {5},
year = {2010},
month = {Mar},
pages = {34-41},
doi = {10.3844/ajptsp.2010.34.41},
url = {https://thescipub.com/abstract/ajptsp.2010.34.41},
abstract = {Problem statement: The literature is reviewed and supports a strong anecdotal relationship between bromocriptine use and psychosis. It is well known that any interference with brain amino acid levels is likely to lead to disorder. Our previous research has shown that bromocriptine produced significant changes in the heart and kidneys amino acid contents. It has been confirmed that the brain amino acids concentrations are influenced by plasma amino acid levels. Therefore, it is the thought of interest to investigate the effect of bromocriptine, sulpiride or their combination on the brain and plasma amino acid concentrations of rat. Approach: The influence of chronic treatment with bromocriptine 20 mg kg day-1 i.p, sulpiride 20 mg kg day-1 i.p. or their combination bromocriptine 20 mg kg day-1 i.p + sulpiride 20 mg kg day-1 i.p. for 6 weeks on free amino acids in the brain and the plasma of rats were carried out. The amino acids were quantified using the LKB 4400 Amino Acid Analyzer and the Hami1ton’s amino acid calibration standards. Results: Bromocriptine significantly decreased the plasma content of glutamic acid, glycine and alanine. (p},
journal = {American Journal of Pharmacology and Toxicology},
publisher = {Science Publications}
}