@article {10.3844/ajptsp.2009.29.37, article_type = {journal}, title = {Cardioprotective Effect of Cucumis trigonus Roxb on Isoproterenol-Induced Myocardial Infarction in Rat }, author = {Thippeswamy, B. S. and Thakker, S. P. and Tubachi, S. and Kalyani, G. A. and Netra, M. K. and Patil, U. and Desai, S. and Gavimath, C. C. and Veerapur, V. P.}, volume = {4}, year = {2009}, month = {Jun}, pages = {29-37}, doi = {10.3844/ajptsp.2009.29.37}, url = {https://thescipub.com/abstract/ajptsp.2009.29.37}, abstract = {Problem statement: Cucumis trigonus Roxb fruit is used for various ailments in Indian traditional system of medicine such as anthelmintic, liver tonic, cardio tonic, appetizer, expectorant and intellect promoting. However, there is lack of information regarding the effect of Cucumis trigonus on the cardiac changes associated with ISO induced myocardial infarction. Approach: The present study was designed to evaluate the cardioprotective potential of ethanol extract of Cucumis Trigonus Roxb fruit (CTE) on the basis of electrocardiographic, biochemical and histopathological parameters in isoproterenol induced myocardial infarction in rats. Male albino sprague dawely rats were pretreated with CTE (75 and 150 mg kg-1) daily for a period of 14 days. After the treatment period, ISO (200 mg kg-1) was subcutaneously injected to rats at an interval of 24 h for two days to induce myocardial injury. After 48 h, rats were anaesthetized with anesthetic ether, electrocardiographic and the levels of biochemical and histological observations of the heart tissues were performed. Results: The activities of serum marker enzymes (ALT, AST, LDH and CPK) were increased significantly (p}, journal = {American Journal of Pharmacology and Toxicology}, publisher = {Science Publications} }