TY  - JOUR
AU  - Zampirolo, Júlio A. 
AU  - Stulzer, Hellen K. 
AU  - Tagliari, Monika Piazzon 
AU  - Schlemper, Valfredo 
AU  - Cechinel-Filho, Valdir 
PY  - 2008
TI  - Antispasmodic Activity of Persea cordata Vell. Mez. (Lauraceae) Fractions on Guinea Pig Ileum Induced by 5-Hydroxytryptamine and Bradykinin 
JF  - American Journal of Pharmacology and Toxicology
VL  - 3
IS  - 4
DO  - 10.3844/ajptsp.2008.229.233
UR  - https://thescipub.com/abstract/ajptsp.2008.229.233
AB  - Problem statement: Persea cordata previously demonstrated antispasmodic action against two neurotransmitters. It is important confirm such action against other neurotransmitters. Approach: Present study described the antispasmodic activity of polar (EtOAc; n-BuOH) and non polar (n-hexane; dichloromethane) fractions from the bark of Persea cordata, against guinea pig ileum contracted by 5-hydroxytryptamine (5-HT) and bradykinin (BK). Results: The results indicated that hexane and dichloromethane fractions caused the most significant relaxant activity against both neurotransmitters tested. Conclusion: The effects seem to be related to the evidenced presence of steroids and terpenes, but additional studies were in progress to identify the active principles of this plant.