@article {10.3844/ajptsp.2008.229.233,
article_type = {journal},
title = {Antispasmodic Activity of Persea cordata Vell. Mez. (Lauraceae) Fractions on Guinea Pig Ileum Induced by 5-Hydroxytryptamine and Bradykinin },
author = {Zampirolo, Júlio A. and Stulzer, Hellen K. and Tagliari, Monika Piazzon and Schlemper, Valfredo and Cechinel-Filho, Valdir},
volume = {3},
year = {2008},
month = {Dec},
pages = {229-233},
doi = {10.3844/ajptsp.2008.229.233},
url = {https://thescipub.com/abstract/ajptsp.2008.229.233},
abstract = {Problem statement: Persea cordata previously demonstrated antispasmodic action against two neurotransmitters. It is important confirm such action against other neurotransmitters. Approach: Present study described the antispasmodic activity of polar (EtOAc; n-BuOH) and non polar (n-hexane; dichloromethane) fractions from the bark of Persea cordata, against guinea pig ileum contracted by 5-hydroxytryptamine (5-HT) and bradykinin (BK). Results: The results indicated that hexane and dichloromethane fractions caused the most significant relaxant activity against both neurotransmitters tested. Conclusion: The effects seem to be related to the evidenced presence of steroids and terpenes, but additional studies were in progress to identify the active principles of this plant. },
journal = {American Journal of Pharmacology and Toxicology},
publisher = {Science Publications}
}