TY  - JOUR
AU  - Furtado, Guilherme Henrique Campos 
AU  - Perdiz, Luciana Baria 
AU  - Medeiros, Eduardo Alexandrino Servolo 
PY  - 2008
TI  - The Effect of a 4th Generation-Cephalosporin Introduction upon the Incidence of Multidrug-Resistant Gram-Negative Bacteria in a Non-Teaching Hospital
JF  - American Journal of Infectious Diseases
VL  - 4
IS  - 4
DO  - 10.3844/ajidsp.2008.267.271
UR  - https://thescipub.com/abstract/ajidsp.2008.267.271
AB  - Problem statement: Antimicrobial resistance is a worrisome situation 
in hospitals around the world and the misuse of certain classes of antimicrobials 
has contributed for this situation. Approach: We performed a 
prospective surveillance study on the incidence of multi-drug resistant bacteria 
before (phase 1) and after (phase 2) the introduction of a 4th-generation cephalosporin 
in a non-teaching hospital. Results: There was a significant 
reduction in the incidence of Enterobacter species (from 1.3 isolates per 100 
patient-days to 0.39 isolates per 100 patient-days, p = 0.01) between the two 
periods. We also observed a reduction in the consumption of ceftazidime (from 
64.3 DDD per 1000 patient-days to 29.6 DDD per 1000 patient-days, p = 0.002) and 
ceftriaxone (from 323.9 DDD per 1000 patient-days to 246.2 DDD per 1000 patient-days, 
p = 0.01). Conclusion: The introduction of a 4th-generation cephalosporin 
in our setting resulted in an important reduction in the incidence of Enterobacter 
species.