TY  - JOUR
AU  - Campbell, Sacha 
AU  - Alexander-Lindo, Ruby 
AU  - Dasgupta, Tara 
AU  - McGrowder, Donovan 
AU  - Gordon, Lorenzo 
PY  - 2008
TI  - The Effect of S-Nitroso-N-Acetylpenicillamine and S-Nitroso-Captopril Co-Administered with Cysteine on Blood Glucose Concentration in an Animal Model 
JF  - American Journal of Biochemistry and Biotechnology
VL  - 4
IS  - 3
DO  - 10.3844/ajbbsp.2008.265.272
UR  - https://thescipub.com/abstract/ajbbsp.2008.265.272
AB  - The study sought to test the hypothesis that co-administration of SNAP and cysteine or CapSNO and cysteine in normoglycaemic rats may further reduce glucose tolerance. An oral glucose tolerance was carried out and the plasma nitrite concentrations were measured and taken as the biochemical markers of in vivo NO formation. The results showed blood glucose levels were significantly elevated at fasting (F2) and 2.5 h time intervals of the oral glucose tolerance test on administration of SNAP at 12.5 mg kg-1 body weight (BW) or CapSNO at 12.5 mg kg-1 BW compared to captopril (12.5 mg kg-1 BW, control). Co-administration of SNAP and cysteine (30 mg kg-1 BW), or CapSNO and cysteine enhanced the postprandial hyperglycemic effect at the 2.0 or 2.5 h time intervals compared with the administration of SNAP or CapSNO only (p