@article {10.3844/ajavsp.2019.69.77,
article_type = {journal},
title = {Oxidative Stress and Reproductive Damage Induced by Lead Acetate in Female Guinea Pig (Cavia porcellus): Curative Effects of Hydroethanolic Extract of Spirulina platensis },
author = {Sorelle, Deutcheu Nienga and Ferdinand, Ngoula and Faustin Pascal, Manfo Tsague and Omer Bebe, Ngouateu Kenfack and Jasmine Laura, Mabou Nguemo and Bertin, Vemo and Herman, Ngoumtsop Victor and Joseph, Tchoumboue},
volume = {14},
number = {1},
year = {2019},
month = {Apr},
pages = {69-77},
doi = {10.3844/ajavsp.2019.69.77},
url = {https://thescipub.com/abstract/ajavsp.2019.69.77},
abstract = {This study was aimed at evaluating the curative effects of Hydroethanolic Extract Of Spirulina platensis (HESP) on the reproductive function of female Guinea pig exposed to oxidative stress. Sixty females, 3-4 months old, weighing 300-400 g were divided into six groups (10 animals/group). The neutral control received distilled water, the negative control was treated with lead acetate at a dose 12 mg/kg.b.w while the positive control was given 12 mg of lead acetate/kg b.w and 100 mg of vitamin C. Groups 4, 5 and 6 were treated with lead acetate at a dose of 12 mg/kg b.w for the first 30 days and then received from the 31st day to the 90th day HESP at doses of 50,100 and 200 mg/kg.b.w respectively once daily. Results revealed that lead caused prominent toxic effects on fertility, deterioration of sex organs as well as a disruption of serum levels of Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH) and progesterone. Lead acetate markedly increased tissues oxidative-stress marker (malondiadehyde), whereas it reduces the activities of antioxidant-enzymes, Superoxide Dismutase (SOD), total peroxidase and catalase. These changes were also accompanied by a significant (p},
journal = {American Journal of Animal and Veterinary Sciences},
publisher = {Science Publications}
}