TY  - JOUR
AU  - Abdullah, Faez Firdaus Jesse 
AU  - Adamu, Lawan 
AU  - Tijjani, Abdulnasir 
AU  - Mohammed, Konto 
AU  - Abba, Yusuf 
AU  - Sadiq, Muhammad Abubakar 
AU  - Zainal, Rosmawati 
AU  - Sabu, Muhammad Jamil Bin 
AU  - Saharee, Abdul Aziz 
AU  - Haron, Abdul Wahid 
PY  - 2014
TI  - Hormonal and Histopathological Alterations in Pituitary Glands and Reproductive Organs of Male and Female Mice Orally Inoculated with Pasteurella Multocida Type B: 2 and its Lipopolysaccharides
JF  - American Journal of Animal and Veterinary Sciences
VL  - 10
IS  - 1
DO  - 10.3844/ajavsp.2015.23.35
UR  - https://thescipub.com/abstract/ajavsp.2015.23.35
AB  - Oral infections of mice as animal model with Pasteurella multocida type B: 2 and its lipopolysaccharides is liable to cause detrimental alterations in the pituitary glands, which results in disruption of reproductive hormonal levels as well as organ functions in the male and female animals; thereby impeding the fertility of at risk animal population. Therefore, this study was designed to evaluate the histopathological modifications in the pituitary glands, reproductive organs and the associated hormonal levels in male and female mice inoculated orally with P. multocida type B: 2 and its lipopolysaccharides. Forty eight mice were divided into three groups consisting of sixteen mice each (8 male and 8 female in separate cages). Group 1 served as the control group and were inoculated orally with 0.4 mL Phosphate Buffer Saline (PBS), group 2 were inoculated orally with 0.4 mL of 109 Colony Forming Unit (CFU) of P. multocida type B: 2 while group 3 were inoculated orally with 0.4 mL of LPS from 109 of colony P. multocida type B: 2. There were significant differences (p