@article {10.3844/ajassp.2012.7.12,
article_type = {journal},
title = {Extra-Bone Marrow Sites of Haemopoeisis: Dihydroartemisinin Effects in Wistar Albino Rats},
author = {Anastasia, Nedosa Uchechukwu and Mohammed, Saleh and Stanislaus, Nedosa Kenechi and Goddy, Njoku and Onyedibe, Ikenna Kenneth and Akah, P. A. and Okoli, C. O.},
volume = {9},
year = {2011},
month = {Nov},
pages = {7-12},
doi = {10.3844/ajassp.2012.7.12},
url = {https://thescipub.com/abstract/ajassp.2012.7.12},
abstract = {Problem statement: Iron is present in ferritin, the storage form of iron in the tissues; in the respiratory cytochrome enzymes; in hemoglobin of the blood and in the myoglobin of muscle Dihydroartemisinin (DHA) has been shown to interact with heme groups in vivo and in vitro. This study investigated the effects of 5 day and 7day oral dihydroartemisinin treatments on the blood and tissues of the lungs, the heart, the liver, the intestines, the spleen and the kidney of Wistar albino rats. The dosage regimens of dihydroartemisinin employed in the study were: A single dosage regimen of 1 mg kg-1; a repeated dosage regimen of 1; 2; 60 and 80 mg kg-1. Approach: The results of the study showed that dihydroartemisinin interacted with the hemoglobin of the blood and the myoglobin of muscle to stimulate new haemopoesis in a concentration, repetition and time dependent manner in the tissues of the lungs, liver, spleen, intestine, heart and kidney of Wistar albino rats which was absent in the control rats. Results: Statistically significant increases were observed in the Packed Cell Volume (PCV) (P},
journal = {American Journal of Applied Sciences},
publisher = {Science Publications}
}