TY  - JOUR
AU  - Chahardehi, Amir Modaressi 
AU  - Ibrahim, Darah 
AU  - Aboulhasani, Fabrid 
AU  - Sulaiman, Shaida Fariza 
PY  - 2013
TI  - Antidepressant-Like Effects of Selected Crude Extracts of Pilea microphylla in Mice Model of Depression
JF  - American Journal of Agricultural and Biological Sciences
VL  - 8
IS  - 1
DO  - 10.3844/ajabssp.2013.75.81
UR  - https://thescipub.com/abstract/ajabssp.2013.75.81
AB  - The present study was undertaken to investigate the effect of selected crude extracts namely, Methanol (ME I), Chloroform Extract (CE II) and Ethyl Acetate (EAE II) extracts of Pilea microphylla on depression in mice. In the present study, the antidepressant effect of P. microphylla was examined due to its rich flavonoid contents in the Urticaceae family using two behavioral models, the Forced Swimming Test (FST) and Tail Suspension Test (TST) in mice. Selected crude extracts from Pilea microphylla produced an antidepressant-like effect, since the acute treatment of mice with extracts by intraperitoneal (i.p.) route significantly reduced the immobility time in the FST (50 and 100 mg kg-1) and TST (50 and 100 mg kg-1), as compared to positive controls (haloperidol and fluoxetine) at 1 and 10 mg kg-1, respectively. The results showed that ME I, CE II and EAE II at dose of 100 mg kg-1 of body weight decreased immobility time with the increase swimming time with respect to the first day (p