Research Article Open Access

CHITOSAN NANOPARTICLES AND THEIR APPLICATIONS IN DRUG DELIVERY: A REVIEW

Sharare Najafi1, Zahra Pazhouhnia1, Omid Ahmadi1, Aydin Berenjian2 and Hoda Jafarizadeh-Malmiri2
  • 1 Sahand University of Technology, Iran
  • 2 University of Waikato, New Zealand
Current Research in Drug Discovery
Volume 1 No. 1, 2014, 17-25

DOI: https://doi.org/10.3844/crddsp.2014.17.25

Submitted On: 24 August 2014
Published On: 8 November 2014

How to Cite: Najafi, S., Pazhouhnia, Z., Ahmadi, O., Berenjian, A. & Jafarizadeh-Malmiri, H. (2014). CHITOSAN NANOPARTICLES AND THEIR APPLICATIONS IN DRUG DELIVERY: A REVIEW. Current Research in Drug Discovery, 1(1), 17-25. https://doi.org/10.3844/crddsp.2014.17.25

Abstract

Chitosan is one of the most popular materials in the field of drug delivery due to its adhesivity and biodegradability. Different types of Chitosan based drug carriers have been conceived for various administration routes, such as oral, nasal, transdermal, parenteral, vaginal, cervical and rectal due to its biocompatibility and biodegradability. Chitosan Nanoparticles (NPs) have long been studied as carriers for systemic and targeted drug delivery. Considerable research efforts have been directed towards developing safe and efficient Chitosan NPs-based particulate drug delivery systems. The results indicated that chemical modification of Chitosan NPs can improve their targeting and bioavailability. The main objectives of this review are to study the Chitosan NPs, their preparation methods, characteristics and modification and finally to evaluate their potential applications in drug delivery systems.

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Keywords

  • Chitosan
  • Nanoparticles
  • Drug Delivery
  • Chemical Modification
  • Application