Is Hydroxychloroquine a Safe and Effective Choice for Covid-19 Prophylaxis
- 1 Faculdade de Medicina de Jundiaí, Brazil
- 2 Universidade Paulista, Brazil
- 3 Unimed Itatiba, Brazil
- 4 Faculdade de Medicina de Teresópolis, Brazil
Published On: 29 July 2020
Copyright: © 2020 Rodrigo Moisés de Almeida-Leite, Tais Rondello Bonatti, Carolina Rodrigues Ponzoni, Ana Cristina da Cunha Korndorfer and Solange Bifani Tavares da Silva. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The authors speculate about the possibility of Hydroxychloroquine as Covid-19 Phrophylaxis in the dose of 400 mg per week. The authors compared the experience of Malaria phrophylaxis in this dose, with acceptable safety profile. Also, we compared in vitro susceptibility of SARS-Cov-2 with that of Plasmodium falciparum. This agent show significant higher potency for the first. Also, the extended Half-life (40-50 days) make it an acceptable choice for prophylaxis. We also cite Brazilian experience with Chloroquinated Salt in the 1950s, its efficacy and feasibility. Lastly, we suggest that clinical trials should be conducted test this hypothesis.
- Pre-exposure Prophylaxis