Mass Production of Uniformly Sized Air-Filled Poly-Lactic Acid Microcapsules Made from Microbubble Templates
- 1 Universidad Especializada de las Américas, Panama
- 2 The Univerity of Tokyo, Japan
- 3 National Institute of Industrial Sciences and Technology, Japan
Copyright: © 2020 Jay Molino, Svetlana Jojlova, Hirofumi Daiguji and Fumio Takemura. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Hollow poly(Lactic Acid) (PLA) microcapsules were fabricated using the bubble template method. In this method, microbubbles nucleated inside droplets of a dichloromethane solution of PLA which were located in a continuous phase of poly(vinyl alcohol). PLA-covered microbubbles formed when PLA adsorbed to the bubble surface by physisorption. Then, the coated microbubbles were spontaneously released from the droplet´s interior into the continuous phase. To increase the production yield of hollow microcapsules in this method, ultrasound was applied to enhance bubble nucleation inside the droplets. Thus to attain uniform hollow PLA microcapsules, the optimum PLA concentration with ultrasound was 30 g L-1, which is higher than that without ultrasound (2 g L-1). At the optimum concentration, the average radius was 0.54 μm, with a polydispersity index of 21.2%. It was found that the equilibrium size of the microbubble template radius was the same with and without ultrasound. The production yield had a tenfold increase when ultrasound was employed.
- 981 Views
- 428 Downloads
- 0 Citations
- Biodegradable Microcapsules
- Drug Delivery
- Mass Production of Hollow Capsules
- Ultrasound Enhanced Fabrication
- Ultrasound Contrast Agents