Research Article Open Access

Cardiotrophin-1 in Patients with Acute Myocardial Infarction

Abdolreza Sotoodeh Jahromi1, Mohammad Shojaie2 and Abdoulhossain Madani2
  • 1 , Afganistan
  • 2 ,
American Journal of Applied Sciences
Volume 7 No. 9, 2010, 1190-1194

DOI: https://doi.org/10.3844/ajassp.2010.1190.1194

Submitted On: 5 April 2010 Published On: 30 September 2010

How to Cite: Jahromi, A. S., Shojaie, M. & Madani, A. (2010). Cardiotrophin-1 in Patients with Acute Myocardial Infarction. American Journal of Applied Sciences, 7(9), 1190-1194. https://doi.org/10.3844/ajassp.2010.1190.1194

Abstract

Problem statement: Myocardial infarction is the combined result of environmental and personal factors. Prothrombotic factors might play an important role in this phenomenon. Inflammation plays a pivotal role in atherosclerosis and coronary heart disease. Cardiotrophin-1 (CT-1), a member of the IL-6 family of cytokines, was identified as a growth factor for cardiac myocytes that induces cardiomyocyte hypertrophy and stimulates cardiac fibroblasts, protects myocytes from cell death. This study was designed to investigate whether plasma concentration of Cardiotrophin-1 (CT-1), in patients who had the first acute myocardial infarction and to analyze their relationship with traditional cardiovascular risk factors. Approach: This study was carried out on 45 patients with Acute Myocardial Infarction (AMI) in their first 24 h of admission as case group and 36 healthy matched individuals were studied as the control. Plasma level of cardiotrophin-1 was determined by enzyme-linked immunosorbent assay and the results were compared. Results: Plasma CT-1 levels in the patients with AMI on admission 615.279±5.109 pmol L-1 were significantly higher than those in the control group 534.767±6.750 pmol L-1 (p = 0.001). Plasma CT-1 level was not correlated with diabetes mellitus, hyperlipidemia, sex, age and smoking. Conclusion: Our findings suggested that high plasma CT-1 level in patients with AMI is indicative of hypercoagulable state that is not related to the traditional cardiovascular risk factors.

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Keywords

  • Cardiotrophin-1
  • myocardial infarction
  • hypercoagulable