OnLine Journal of Biological Sciences

Evaluation of the Cytisus Triflorus (Lam.) Polyphenols Cicatrizing Activity on Experimental Thermal Burns in New Zealand Rabbits

Sihem Khadri, Nafissa Boutefnouchet, Youcef Hadef and Zouhir Djerrou

DOI : 10.3844/ojbsci.2018.298.303

OnLine Journal of Biological Sciences

Volume 18, Issue 3

Pages 298-303

Abstract

The present study aimed to evaluate the healing properties of the medicinal plant Cytisus triflorus widely used in the traditional treatment of wound healing. The principle of study is the application of the polyphenol extract of this plant prepared with vaseline in the form of a dermal ointment on thermal burns of second deep degree (circular of 379.94 mm2 in diameter) previously caused experimentally by a hot cylindrical metal on the backs of new Zealand rabbits. Each rabbit receives four burns two dorsal and two lumbar which were treated immediately after burning with a quantity of 0.5 g of vaseline (positive control), 0.5 g of commercial ointment skin MEBO (reference), 0.5 g of poly phenolic extract and untreated burn served as a negative control. The treatments were done daily until the complete epithelialization of the wound. The evaluation of the healing process was based on the healing time and the burn contraction percentage calculated every two days. According to the obtained results, the vaseline shows a better percentage of burn contraction during the inflammatory phase (2nd-6th day) with a significant effect (p<0.05) as compared to the reference drug MEBO and the Polyphenol extract that stimulated burn contraction from the 8th day (end of the inflammatory phase) significantly compared with vaseline and untreated burns. However, poly phenolic extract significantly appears to be more effective than the reference drug by shortening the epithelialization period (19 days) as compared to other products; MEBO drug (20 days), pure vaseline (24 days) and untreated burns (25 days). The study concludes that Cytisus triflorus polyphenols promote burn wound healing in rabbit’s model.

Copyright

© 2018 Sihem Khadri, Nafissa Boutefnouchet, Youcef Hadef and Zouhir Djerrou. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.