Anti-Proliferative Activity of Zerumbone Against Tumour Cell Lines
Adel Sharaf Al-Zubairi
DOI : 10.3844/ojbsci.2018.123.129
OnLine Journal of Biological Sciences
Volume 18, Issue 2
Zerumbone (ZER) is a cytotoxic phytochemical component extracted from the tropical herbal plant, Zingiber Zerumbet smith. It has been identified as an active anticancer compound. This study was aimed to evaluate in vitro the anti-proliferative activity of this bioactive compound, zerumbone, on seven cancer cell lines namely: CEMss (T4-lymphoplastoid), Chinese Hamster Ovary (CHO), 3T3 (mouse fibroblast), WEHI-3 (murine monomyelocytic leukemia), HeLa (Human cervical cancer), MCF-7 (human breast cancer) and MDA-MB-231 (human mammary cancer-estrogen negative). The antiproliferative activity of ZER was evaluated using 3-[4,5-dimethylthizol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay, together with the commercially available anticancer drug Cisplatin as a control drug. The most sensitive cells to ZER were found to be WEHI-3B, 3T3 and Hela cell lines with an IC50 of 5, 6 and 6.4 µg mL-1, respectively, followed by CEMss cell lines with an IC50 of 12 µg mL-1. This indicates the possible potential use of ZER for treatment of hematological cancers in addition to the cervical cancer. Meanwhile, ZER was found to be less toxic to the normal cell lines CHO.
© 2018 Adel Sharaf Al-Zubairi. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.