OnLine Journal of Biological Sciences

Physicochemical Characteristics and Sub Chronic Oral Toxicity of Pistacia lentiscus L. Vegetable Oil in Rabbits

Maameri Zineb, Zouhir Djerrou, Sofiane Habibatni, Foulla Riachi, Hadria Djaalab and Youcef Hamdi Pacha

DOI : 10.3844/ojbsci.2016.43.48

OnLine Journal of Biological Sciences

Volume 16, Issue 1

Pages 43-48

Abstract

Pistacia lentiscus vegetable oil is a well known natural product in Algerian traditional medicine. It is widely used in the treatment of back pain, respiratory problems and skin burns. The aim of this study was the determination of some physicochemical parameters and the investigation of sub-chronic oral toxicity of this fatty oil in rabbits. The physico-chemical parameters obtained for this oil were similar to those reported for similar oils [density: 0.915, refractive index: 1.46; acid value (mg KOH/g): 8.4; saponification value (mg KOH/g): 187.5]. The sub-chronic toxicity test conducted in rabbits at different doses (0.5, 1 and 2 mL kg-1) for 28 days via oral route did not result in any signs of toxicity. The biochemicals results indicate that this oil maintain rates of ALT and AST in the physiological norms. A significant decrease in blood glucose was registered, but always within the physiological standards. Other experimental studies are required to accomplish the pharmacotoxicological profile of this vegetable oil which is in spreading use.

Copyright

© 2016 Maameri Zineb, Zouhir Djerrou, Sofiane Habibatni, Foulla Riachi, Hadria Djaalab and Youcef Hamdi Pacha. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.