Research Article Open Access

Proposed Insights in the Pharmaco-Dynamic Theory of Ascorbate Pro-Oxidant Activity

Kheir Eddine Kerboua1, Fatma Haiba1, Fatima Bendjemia1, Mimouna Kerrache1 and Amina Boumediene1
  • 1 Military University Hospital of Oran, Algeria

Abstract

Ascorbate pro-drug theory promising possible effective and nontoxic treatment is intensively examined and centered on the importance of both extracellular and intra-cellular effects of ascorbate. In this study, we sought to determine the in vitro cell responsiveness in a plasma free milieu with or without an extracellular catalyst and/or hydrogen peroxide. This project brought to light how ascorbic acid would react to in a Red Blood Cell (RBC) suspension by using the two anti-oxidant pathways. We demonstrated that while ascorbate doesn’t require an extracellular metal catalyst to induce cell damage via the lipid peroxidation pathway, the protein-centered metal pathway could be enhanced by a divalent cation, hydrogen peroxide or both. The current lack of understanding of ascorbate potential mechanism excites us to propose some insights for the vitamine C pharmacologic dose pro-oxidant activity.

OnLine Journal of Biological Sciences
Volume 16 No. 1, 2016, 1-9

DOI: https://doi.org/10.3844/ojbsci.2016.1.9

Submitted On: 10 August 2015 Published On: 24 November 2015

How to Cite: Kerboua, K. E., Haiba, F., Bendjemia, F., Kerrache, M. & Boumediene, A. (2016). Proposed Insights in the Pharmaco-Dynamic Theory of Ascorbate Pro-Oxidant Activity. OnLine Journal of Biological Sciences, 16(1), 1-9. https://doi.org/10.3844/ojbsci.2016.1.9

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Keywords

  • Ascorbic Acid
  • Pharmacodynamics
  • Pro-Oxidant
  • Biochemical
  • Mechanical and Enzymatic Biomarkers
  • Intracellular and Extracellular Effects
  • Human Erythrocyte