Research Article Open Access

THE PRESENCE OF ANTI-PHOSPHATIDYLETHANOLAMINE ANTIBODIES IN ACUTE MYOCARDIAL INFARCTION

Abdolreza Sotoodeh Jahromi1, Mohammad Shojaei1, Mohammad Reza Farjam1 and Abdolhossien Madani2
  • 1 Jahrom University of Medical Science, Iran
  • 2 Hormozgan University of Medical Science, Iran

Abstract

Acute Myocardial Infarction (AMI) is a clinical manifestation of coronary atherothrombosis and is the important causes of death. Many factors play a role in AMI. Anti-Phospholipid (aPL) antibodies may act in the induction of immunological response leading to the development of AMI. Anti-Phosphatidylethanolamine (aPEA) antibody has been detected in various autoimmune diseases and anti-phospholipid antibody syndrome. The study of aPEA antibody in AMI might shed light on etiologic mechanisms in the pathogenesis of coronary atherothrombosis and AMI. This study was aimed to evaluate whether prevalence of aPEA antibodies, in patients with AMI and to analyze their relationship with traditional cardiovascular risk factors. The prevalence of aPEA IgG and IgM in a well characterized group of patients with AMI as a case group and in age and sex matched healthy subjects as a control group. Sera from two groups were tested to evaluate the presence of aPEA IgG and IgM isotypes by ELISA method. The frequencies of positive test for aPEA IgG were 12.22 and 2.22% among patients and controls respectively with significant difference (p = 0.007). The aPEA IgM frequencies were 3.33 and 0.00% in patients and the controls, with significant difference (p = 0.005). According to the results of this study, aPEA antibodies have a role in AMI, independent risk factors for AMI, which may represent a link between autoimmunity and coronary atherothrombosis. Further studies with larger sample size of patients and healthy people are needed to explore the role of aPEA antibodies in coronary atherothrombosis.

OnLine Journal of Biological Sciences
Volume 13 No. 4, 2013, 126-130

DOI: https://doi.org/10.3844/ojbsci.2013.126.130

Submitted On: 29 September 2013 Published On: 21 October 2013

How to Cite: Jahromi, A. S., Shojaei, M., Farjam, M. R. & Madani, A. (2013). THE PRESENCE OF ANTI-PHOSPHATIDYLETHANOLAMINE ANTIBODIES IN ACUTE MYOCARDIAL INFARCTION. OnLine Journal of Biological Sciences, 13(4), 126-130. https://doi.org/10.3844/ojbsci.2013.126.130

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Keywords

  • Anti-Phosphatidylethanolamine (aPEA) Antibodies
  • Acute Myocardial Infarction (AMI)
  • Anti-Phospholipid (aPL) Antibodies
  • Cardiovascular Ischemia
  • Coronary Atherothrombosis