OnLine Journal of Biological Sciences

FREE ENERGY MEASUREMENT DISTINGUISHES NORMAL FROM CANCER CELL, OFFERING A NEW PERSPECTIVE FOR CURING CANCER

Kambiz Afrasiabi and Jonathan Melekh-Shalom

DOI : 10.3844/ojbsci.2013.121.125

OnLine Journal of Biological Sciences

Volume 13, Issue 4

Pages 121-125

Abstract

The interplay of the second law of thermodynamics with the normal state and the methodology needed for the measurement of free energy of normal and malignant cells and its practical implications has not been clearly addressed in current literature. The second law of thermodynamics is one of the most fundamental laws governing the known universe at all levels. A normal cell has an exceptional ability to minimize the speed of rise in entropy to saturation of the limits of the second law. By virtue of this law, any normal resting cell is at a maximum allowable free energy. In this regard mitosis could be viewed as an attempt to maximize the lowered cellular free energy. Here we present the result of our first series of measurements, which show a significant measurable difference between the free energy of normal and malignant cells using an Olympus 510 Argon laser to calculate a diffusion correlation as well as direct visualization of motion of malignant and normal cells cultured overnight in collagen mesh. We found a significantly higher vibratory motion of the normal cells after correction for confounding factors. We also propose a new way to increase the free energy of the malignant cell to match that of its normal counterpart. This could offer hope for cure by conversion of distorted energetics of the malignant cell.

Copyright

© 2013 Kambiz Afrasiabi and Jonathan Melekh-Shalom. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.